Hodgkin - Huxley axon

Physical System

From http://www.mbl.edu

Model

Hodgkin-Huxley cable equations

Simulation

Representation

	create axon
	axon {
		nseg = 75
		diam = 100
		L = 20000
		insert hh
	}

Using the Representation

Run NEURON with above spec.

Exercises

1) Stimulate with current pulse and see a propagated action potential.

The basic tools you'll need from the NEURON Main Menu :
Tools / Point Processes / Manager / Point Manager to specify stimulation
Graph / Voltage axis and Graph / Shape plot to create graphs of v vs t and v vs x.
Tools / RunControl to run the simulation
Tools / Movie Run to see a smooth evolution of the space plot in time.

2) Change excitability by adjusting sodium channel density.

Tool needed:
Tools / Distributed Mechanisms / Viewers / Shape Name

3) Use two current electrodes to stimulate both ends at the same time.

4) Up to this point, the model has used a very fine spatial grid (nseg = 75).
Change nseg to 15 and see what happens.

Help reference


NEURON hands-on course
Copyright © 1998-2007 by N.T. Carnevale and M.L. Hines, all rights reserved.